It is possible to use our guide with 4 inch hole saws, only if you remove one of the plates.
The suction cup side will have a triangular wedge like constraint on the hole saw. This is enough to hold the hole saw in place.
But overall, this is not the ideal use of a guide. Can be a plan B in case you can’t find a guide.
Or you can make a 4 inch hole in a piece of plywood, and use it as a guide. Using some painters tape, you can fix your plywood guide to the surface.